Hiromi Sakai Selected Research

Adenosine Diphosphate (ADP)

10/2019

Combination therapy using fibrinogen γ-chain peptide-coated, ADP-encapsulated liposomes and hemoglobin vesicles for trauma-induced massive hemorrhage in thrombocytopenic rabbits.

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Hiromi Sakai Research Topics

Disease

21	Hemorrhagic Shock 01/2024 - 09/2002
11	Hemorrhage 06/2022 - 04/2011
7	Inflammation (Inflammations) 09/2023 - 03/2007
6	Hypoxia (Hypoxemia) 01/2022 - 05/2003
5	Shock 01/2024 - 09/2004
5	Neoplasms (Cancer) 09/2023 - 01/2009
5	Port-Wine Stain (Nevus Flammeus) 01/2023 - 03/2017
4	Infections 01/2022 - 10/2008
4	Poisoning 01/2022 - 10/2021
3	Anaphylaxis (Anaphylactic Shock) 01/2024 - 01/2007
3	Acute Kidney Injury (Acute Renal Failure) 09/2023 - 12/2021
3	Anemia 06/2022 - 10/2019
3	Fibrosis (Cirrhosis) 01/2022 - 02/2011
3	Wounds and Injuries (Trauma) 10/2019 - 01/2016
3	Reperfusion Injury 01/2019 - 02/2009
3	Fetal Hypoxia 07/2017 - 10/2012
2	Hypersensitivity (Allergy) 01/2024 - 01/2007
2	Exsanguination 01/2024 - 01/2020
2	Death (Near-Death Experience) 12/2023 - 01/2019
2	Atrial Remodeling 04/2023 - 01/2019
2	Hemolysis 01/2022 - 07/2002
2	Acidosis 01/2022 - 01/2019
2	Body Weight (Weight, Body) 11/2018 - 07/2014
2	Pancreatitis 11/2018 - 01/2016
2	Fetal Growth Retardation (Intrauterine Growth Retardation) 07/2017 - 10/2015
2	Pre-Eclampsia (Preeclampsia) 07/2017 - 10/2015
2	Lung Injury 01/2016 - 09/2009
2	Liver Cirrhosis (Hepatic Cirrhosis) 02/2011 - 11/2010
1	Sarcopenia 04/2024
1	Muscular Atrophy (Muscle Atrophy) 04/2024
1	Burns 01/2023
1	Methemoglobinemia 04/2022
1	Chronic Renal Insufficiency 01/2022
1	Bronchiolitis 01/2022
1	Postpartum Hemorrhage 11/2021

Drug/Important Bio-Agent (IBA)

40	Hemoglobins (Hemoglobin)IBA 01/2024 - 07/2002
21	Oxygen (Dioxygen)IBA 01/2024 - 07/2002
12	Carbon MonoxideIBA 04/2024 - 05/2009
7	Liposomes (Liposome)IBA 01/2024 - 01/2009
6	AlbuminsIBA 04/2023 - 09/2004
5	Photosensitizing Agents (Photosensitizers)IBA 01/2023 - 03/2017
5	Blood Substitutes (Artificial Blood)IBA 01/2022 - 04/2015
5	Human Serum Albumin FDA LinkGeneric 01/2021 - 02/2003
5	SolutionsIBA 01/2019 - 05/2003
5	CytokinesIBA 01/2016 - 02/2012
4	LipidsIBA 01/2024 - 01/2007
4	liposome-encapsulated hemoglobinIBA 04/2023 - 01/2019
4	MethemoglobinIBA 01/2022 - 01/2009
3	Messenger RNA (mRNA)IBA 04/2024 - 12/2006
3	Immunoglobulin M (IgM)IBA 01/2024 - 03/2011
3	AntidotesIBA 01/2022 - 10/2021
3	Therapeutic UsesIBA 01/2022 - 08/2014
3	Cyanides (Isocyanides)IBA 01/2022 - 10/2021
3	SuspensionsIBA 12/2021 - 07/2014
2	Cisplatin (Platino)FDA LinkGeneric 09/2023 - 12/2021
2	AntioxidantsIBA 09/2023 - 01/2016
2	Free RadicalsIBA 01/2023 - 04/2015
2	Phenobarbital (Luminal)FDA Link 01/2022 - 10/2008
2	EnzymesIBA 01/2022 - 02/2009
2	Electron Transport Complex IV (Cytochrome c Oxidase)IBA 01/2022 - 10/2021
2	Lactic Acid (Lactate)FDA LinkGeneric 01/2021 - 12/2006
2	Proteins (Proteins, Gene)FDA Link 10/2020 - 01/2016
2	Interleukin-6 (Interleukin 6)IBA 12/2015 - 02/2012
2	Ringer's LactateIBA 02/2012 - 12/2006
2	Complement System Proteins (Complement)IBA 04/2011 - 01/2007
2	Carbon Tetrachloride (Tetrachloromethane)IBA 02/2011 - 11/2010
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 12/2006 - 09/2004
1	MyostatinIBA 04/2024
1	Immunoglobulin G (IgG)IBA 01/2024
1	Phospholipids (Phosphatides)FDA LinkGeneric 01/2024
1	Reducing AgentsIBA 01/2023
1	APTIBA 04/2022
1	Nitroglycerin (Dynamite)FDA LinkGeneric 04/2022
1	Glucose (Dextrose)FDA LinkGeneric 01/2022
1	AMP-Activated Protein KinasesIBA 01/2022
1	Hydrogen Sulfide (Sulfide, Hydrogen)IBA 01/2022
1	Membrane LipidsIBA 01/2022
1	Hemin (Panhematin)FDA Link 01/2022
1	NF-E2-Related Factor 2IBA 01/2022
1	Interleukin-17 (Interleukin 17)IBA 01/2022
1	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 01/2022
1	Cyclosporine (Ciclosporin)FDA LinkGeneric 01/2022
1	Starch (Cornstarch)IBA 11/2021

Therapy/Procedure

23	Resuscitation 01/2024 - 09/2002
7	Therapeutics 01/2022 - 10/2015
5	Dye Lasers 01/2023 - 03/2017
4	Intravenous Injections 01/2024 - 10/2012
3	Artificial Respiration (Mechanical Ventilation) 01/2024 - 01/2017
3	Hemodilution 06/2022 - 05/2003
2	Cell- and Tissue-Based Therapy (Cell Therapy) 04/2024 - 01/2022
2	Injections 01/2024 - 03/2011
2	Pneumonectomy (Lung Volume Reduction) 01/2024 - 01/2020
2	Lasers (Laser) 01/2023 - 03/2017
2	Intraosseous Infusions 06/2022 - 01/2020
2	Blood Transfusion (Blood Transfusions) 04/2022 - 01/2022
2	Cesarean Section (Caesarean Section) 11/2021 - 07/2017
2	Ligation 01/2021 - 04/2011
1	Euthanasia (Mercy Killing) 04/2022
1	Intravenous Infusions 01/2022
1	Lung Transplantation 01/2022